郑天鹏，男，医学博士，教授，主任医师，中南大学湘雅医院博士生导师，欧洲杯压住平台杰出青年人才，内分泌与代谢专业优秀学术带头人，广西糖尿病系统医学重点实验室PI,欧洲杯压住平台第二附属医院内分泌科副主任。从事内分泌与代谢专业的临床和科研工作，临床主要研究方向是糖尿病足的综合性诊疗，科研方面主要研究方向是糖尿病及其相关并发症的发生机制。迄今为止，以第一作者和（或）通讯作者身份共发表SCI论著18篇，累计影响因子85.6分，包括内分泌与代谢领域顶级期刊Diabetes Care（IF：11.857）、JCEM以及相关领域知名杂志Psychotherapy and psychosomatics（IF：13.122）、The Journal of Clinical Psychiatry、Metabolism，Cardiovascular diabetology等，上述论文研究内容主要覆盖糖尿病、糖尿病肾病、糖尿病大血管病变、糖尿病性骨质疏松、糖尿病性认知功能障碍、糖尿病性抑郁等疾病的流行病学和发病机制研究。目前获得国家自然科学基金2项（面上项目和地区项目各1项），广西自然科学基金1项，广西科学研究与技术开发计划1项。2015年度获得中华医学会糖尿病学分会授予的“2014年度中国糖尿病十大研究最具影响力研究奖”，2019年度获得广西青年科技奖。

发表论文：所有共同第一作者均加注上标“#”，通讯作者及共同通讯作者均加注上标“*”。

1.Sun C, Xiao Y, Li J, Ge B, Chen X, Liu H,Zheng T（郑天鹏）*. Nonenzymatic function of DPP4 in diabetes-associated mitochondrial dysfunction and cognitive impairment. Alzheimers Dement. 2021 Aug 10.

2.Tianpeng Zheng*,Xu Chen, Bo Ge, Bo Chen, Linyuan Qin,Li Tian , Yun Gao ,Xueping Hu, Liuping Xiao, Haidong Pan, Yujie Chen.Association between plasma dipeptidyl peptidase-4 activity to brain-derived neurotrophic factor ratio and depressive symptoms in middle-aged and older adults with normal glucose tolerance: A cross-sectional study.World J Biol Psychiatry. 2020 Oct;21(8):642-650.

3.Tianpeng Zheng*, Bo Ge, Linyuan Qin, Bo Chen, Li Tian, Yun Gao, Liuping Xiao, Xueping Hu, Haidong Pan, Yujie Chen.Association of Plasma DPP4 Activity and Brain-Derived Neurotrophic Factor With Moderate to Severe Depressive Symptoms in Patients With Type 2 Diabetes: Results From a Cross-Sectional Study.Psychosom Med.2020 May;82(4):350-358.

4.Xiao L,Ge B,Chen X,Chen B,Qin L,Hu X,Pan H,Chen Y,Tian L,Gao Y,Zheng T*.The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance. Front Aging Neurosci.2019 Mar 4; 11:33.

5.Zheng T*, Ge B, Liu H, Chen B, Qin L, Xiao L, Song J: Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China. Cardiovascular diabetology 2018;17:84

6.Yang L, Song J, Zhang X, Xiao L, Hu X, Pan H, Qin L, Liu H, Ge B, Zheng T*: Association of Serum Angiopoietin-Like Protein 8 With Albuminuria in Type 2 Diabetic Patients: Results From the GDMD Study in China. Frontiers in endocrinology 2018;9:414

7.Zheng T*, Liu H, Qin L, Chen B, Zhang X, Hu X, Xiao L, Qin S: Oxidative stress-mediated influence of plasma DPP4 activity to BDNF ratio on mild cognitive impairment in elderly type 2 diabetic patients: results from the GDMD study in China. Metabolism: clinical and experimental 2018;87:105-112

8. Zheng T*, Chen B, Yang L, Hu X, Zhang X, Liu H, Qin L: Association of plasma dipeptidyl peptidase-4 activity with non-alcoholic fatty liver disease in nondiabetic Chinese population. Metabolism: clinical and experimental 2017;73:125-134

9. Chen B#, Zheng T#*, Qin L, Hu X, Zhang X, Liu Y, Liu H, Qin S, Li G, Li Q: Strong Association between Plasma Dipeptidyl Peptidase-4 Activity and Impaired Cognitive Function in Elderly Population with Normal Glucose Tolerance. Frontiers in aging neuroscience 2017;9:247

10. Zheng T*, Qin L, Chen B, Hu X, Zhang X, Liu Y, Liu H, Qin S, Li G, Li Q: Plasma Dipeptidyl Peptidase-4 Activity, a Novel Biomarker or Even a Possible Therapeutic Target for Depression in Type 2 Diabetic Patients: Results from a Cross-Sectional Study in China. Psychotherapy and psychosomatics 2017;86:254-256

11. Zheng T*, Qin L, Chen B, Hu X, Zhang X, Liu Y, Liu H, Qin S, Li G, Li Q: Association of Plasma DPP4 Activity With Mild Cognitive Impairment in Elderly Patients With Type 2 Diabetes: Results From the GDMD Study in China. Diabetes care 2016;39:1594-1601

12. Zheng T, Liu Y, Qin S, Liu H, Zhang X, Zhao H: Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of diabetic nephropathy in Chinese patients with newly diagnosed type 2 diabetes: A cross-sectional study. Diabetes & vascular disease research 2016;13:127-136

13. Zheng T*, Liu Y, Qin S, Liu H, Yang L, Zhang X, Li G, Li Q: Increased Dipeptidyl Peptidase-4 Activity Is Associated With High Prevalence of Depression in Middle-Aged and Older Adults: A Cross-Sectional Study. The Journal of clinical psychiatry 2016;77:e1248-e1255

14. Zheng TP*, Liu YH, Yang LX, Qin SH, Liu HB: Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of subclinical atherosclerosis in Chinese patients with newly diagnosed type 2 diabetes: a cross-sectional study. Atherosclerosis 2015;242:580-588

15. Zheng T*, Yang L, Liu Y, Liu H, Yu J, Zhang X, Qin S: Plasma DPP4 Activities Are Associated With Osteoporosis in Postmenopausal Women With Normal Glucose Tolerance. The Journal of clinical endocrinology and metabolism 2015;100:3862-3870

16. Zheng T, Chen T, Liu Y, Gao Y, Tian H: Increased plasma DPP4 activity predicts new-onset hypertension in Chinese over a 4-year period: possible associations with inflammation and oxidative stress. Journal of human hypertension 2015;29:424-429

17. Zheng T, Baskota A, Gao Y, Tian H, Yang F: Increased plasma dipeptidyl peptidase 4 activities predict new-onset microalbuminuria in association with its proinflammatory effects in Chinese without diabetes: a four-year prospective study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2015;30:460-466

18. Zheng T, Baskota A, Gao Y, Chen T, Tian H, Yang F: Increased plasma DPP4 activities predict new-onset hyperglycemia in Chinese over a four-year period: possible associations with inflammation. Metabolism: clinical and experimental 2015;64:498-505

19. Zheng TP, Yang F, Gao Y, Baskota A, Chen T, Tian HM, Ran XW: Increased plasma DPP4 activities predict new-onset atherosclerosis in association with its proinflammatory effects in Chinese over a four year period: A prospective study. Atherosclerosis 2014;235:619-624

20. Zheng T, Gao Y, Baskota A, Chen T, Ran X, Tian H: Increased plasma DPP4 activity is predictive of prediabetes and type 2 diabetes onset in Chinese over a four-year period: result from the China National Diabetes and Metabolic Disorders Study. The Journal of clinical endocrinology and metabolism 2014;99:E2330-2334

21. Yang F, Zheng T#, Gao Y, Baskota A, Chen T, Ran X, Tian H: Increased plasma DPP4 activity is an independent predictor of the onset of metabolic syndrome in Chinese over 4 years: result from the China National Diabetes and Metabolic Disorders Study. PloS one 2014;9:e92222

22. Zheng T, Gao Y, Tian H: Relationship between blood lipid profiles and pancreatic islet beta cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study. BMC public health 2012;12:634

获得基金：

1. DPP4通过下调Foxp3基因表达抑制Treg细胞免疫调节作用的机制研究，国家自然科学基金地区项目。

2. DPP4非酶学功能介导的PAR2/GSK-3β/PGC-1α信号通路在2型糖尿病认知功能障碍中的作用及机制研究，国家自然科学基金面上项目。

3. DPP4 活性增高对血管内皮细胞功能影响及其机制研究，广西自然科学基金青年项目。

4. 2型糖尿病高危人群规范化诊疗方案的建立及其卫生经济学评价，广西科学研究与技术开发计划。

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