不孕女性 BMI 与其卵泡浆内单精子注射助孕妊娠率的相关性分析

赵明明,史新丽,仵金华

(商丘市睢阳区中心医院妇产科,河南 商丘 476100)

摘要 目的:分析不孕女性体质量指数(BMI)与其卵泡浆内单精子注射助孕妊娠率的相关性。 方法:选取 119 例不孕女性,均行卵泡浆内单精子注射助孕,依据 BMI 将其分为两组,其中 BMI≤23.9 kg/ m 2 的 80 例作为正常组,BMI>23.9 kg/ m 2 的 39 例作为超重组。 比较两组 Gn 总量、Gn 刺激时长、HCG 日 E 2 、正常受精率、获卵数、全胚胎冷冻率、临床妊娠率、生化妊娠率、自然流产率、活产率、早产率。 结果:正常组 Gn 刺激时长、Gn 总量少于超重组,获卵数多于超重组,HCG 日 E 2 高于超重组,全胚胎冷冻率高于对照组,以上差异均有统计学意义(P<0.05);两组临床妊娠率、生化妊娠率、自然流产率、活产率、早产率与超重组比较,均无统计学差异(P>0.05)。 结论:不孕女性中体重正常者治疗期间的各项指标优于超重者,但不同 BMI 对于妊娠率、妊娠结局影响不明显。

关键词: 不孕女性;体质量指数;卵泡浆内单精子注射助孕;妊娠率

中图分类号:R711.6 文献标志码:A 文章编号:1008-2409(2022)03-0085-05

Correlation between BMI and pregnancy rate by intrafollicular sperm injection in infertile women

ZHAO Mingming, SHI Xinli, WU Jinhua. ( Dept. of Obstetrics & Gynecology, the Central Hospital of Suiyang District, Shangqiu 476100, China)

Abstract Objective: To analyze the correlation between the body mass index(BMI)and the pregnancy rate of intrafollicular sperm injection in infertile women. Methods: A total of 119 infertile women underwent intracytoplasmic sperm injection to assist pregnancy were divided into two groups according to different BMI. Of whom, 80 patients whose BMI≤23.9 kg/ m 2 were included in the normal group, and another 39 patients with BMI>23.9 kg/ m 2 were included in the overweight group. Total Gn, Gn stimulation duration, E 2 at HCG d, normal fertilization rate, number of eggs retrieved, whole embryo freezing, clinical pregnancy rate, biochemical pregnancy rate, spontaneous abortion rate, live birth rate and preterm birth rate were compared between both groups. Results: The normal group had shorter duration of Gn stimulation, less total amount of Gn, higher number of eggs retrieved and higher E 2 at HCG d than the overweight group, and the freezing rate of whole embryos was higher than that of the control group, which were all of statistical differences(P<0.05); and there was no statistical difference in clinical pregnancy rate, biochemical pregnancy rate, spontaneous abortion rate, live birth rate and preterm birth rate between the two groups(P>0.05). Conclusions: The indexes of infertile women with normal weight during treatment were better than those with overweight, but different BMI had no significant effect on pregnancy rate and pregnancy outcomes.

Keywords: infertile women; body mass index ( BMI); intrafollicular sperm injection for assisted pregnancy; pregnancy rate

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